Anoek Friskes

Visualizing homology search in living cells

This study visualizes homology search dynamics in living human cells using GFP-MND1, revealing filament structures that resolve over time and depend on RAD54L and cohesin.

Centriole structural integrity defects are a crucial feature of Hydrolethalus Syndrome

This study shows that HYLS1 mutations cause centriole structural defects leading to ciliary dysfunction and developmental issues in mice, mirroring human Hydrolethalus Syndrome.

Widespread chromatin context-dependencies ofDNA double-strand break repair proteins

A multiplexed screen reveals how dozens of proteins sense the local chromatin context to tune the balance between two DNA repair pathways.

Chromatin context-dependent effects of epigenetic drugs on CRISPR-Cas9 editing

This study identifies 67 epigenetic drugs that modulate CRISPR-Cas9 editing efficiency and repair outcomes based on chromatin context in human cells.

Perturbations in 3D genome organization can promote acquired drug resistance

The paper shows that disrupting nuclear lamina association promotes ABCB1 gene derepression and taxol resistance in RPE cells.

Unexpected gene activation following CRISPR-Cas9-mediated genome editing

This study reports that lentiviral-based CRISPR-Cas9 vectors can integrate into the target genomic location, unexpectedly activating the target gene.