Serafima Dubnov

The paper profiles microRNA expression in human brain cell types to reveal cell-type specificity and age-related changes.

The paper introduces bioIB, a framework using the Information Bottleneck method to extract compressed, signal-informative representations of scRNA-seq data, demonstrating its utility in diverse biological contexts.

This study evaluates the reproducibility and clinical utility of blood mRNA-based gene signatures for Parkinson's disease classification, finding modest performance due to inter-individual variability.

This study uses spatial transcriptomics to analyze tumor microenvironment remodeling dynamics in triple-negative breast cancer, identifying early stromal programs as potential therapeutic targets.

The paper shows maternal prenatal stress causes sex-dependent changes in tRNA fragments and cholinergic pathways in newborns.

This study shows that Klotho knockout affects brain microRNAs and tRNA fragments linked to aging and Alzheimer's disease in both mice and humans.

This study identifies RPL24 as a regulator of miR processing and tRF production, showing its interaction with DDX5 and its effect on miR levels and tRF profiles in human and plant cells.

This study identifies LysTTT-5tRF and miR-194-5p as co-regulators of hepatic steatosis through beta-Klotho and Perilipin 2, showing their cooperative roles in lipid metabolism.

The paper identifies sex-specific changes in cholinergic-targeting tRNA fragments in Alzheimer's disease, linking them to cholinergic neuron loss and dementia.