JENNIE SMITH

Microglia respond to elevated intraocular pressure and synapse loss in the visual thalamus in a mouse model of glaucoma.

This study examines microglia morphology and gene expression in the visual thalamus of glaucoma mice, finding morphological changes and immune gene upregulation linked to intraocular pressure and synapse loss.

Amyloid Beta Pathology Accelerates Alterations in the Visual Pathway of the 5xFAD Mouse

This study examines the impact of amyloid beta pathology on the visual pathway in 5xFAD mice, finding modest dysfunction and potential compensatory mechanisms.

Loss of retinogeniculate synaptic function in the DBA/2J mouse model of glaucoma.

This study examines how glaucoma affects retinal ganglion cell (RGC) signaling to the dLGN in DBA/2J mice, finding functional deficits linked to intraocular pressure.

Neuronal and synaptic plasticity in the visual thalamus in mouse models of glaucoma.

This study examines how neuronal and synaptic function in the thalamus changes in mouse glaucoma models, finding age- and IOP-dependent alterations in intrinsic excitability and synaptic currents.

Structural and functional plasticity in the dorsolateral geniculate nucleus of mice following bilateral enucleation

This study examines structural and functional changes in thalamocortical neurons following bilateral enucleation in mice, revealing degeneration and compensatory plasticity.

Early-Stage Ocular Hypertension Alters Retinal Ganglion Cell Synaptic Transmission in the Visual Thalamus

This study shows that early-stage ocular hypertension causes pre- and post-synaptic functional and structural changes at retinogeniculate synapses before significant RGC loss.