Matthew J. Van Hook

The paper examines Aβ pathology and microglial responses in visual brain regions of 5xFAD mice, finding significant Aβ accumulation and microglial polarization in image-forming regions but not in non-image-forming regions.

This study investigates compensatory plasticity in the dorsolateral geniculate nucleus of glaucomatous mice, finding increased intrinsic excitability and reduced inhibition in relay neurons despite diminished retinal input.

This study examines microglia morphology and gene expression in the visual thalamus of glaucoma mice, finding morphological changes and immune gene upregulation linked to intraocular pressure and synapse loss.

This study examines the impact of amyloid beta pathology on the visual pathway in 5xFAD mice, finding modest dysfunction and potential compensatory mechanisms.

The paper investigates inhibitory synaptic changes in the dLGN of glaucomatous mice and finds non-uniform upregulation of GABA receptors at inhibitory synapses.

This study shows human retinal ganglion cells (hRGCs) use chemotropic cues for axon guidance and regeneration, involving Netrin-1/DCC signaling and mTOR pathway activation.

This study examines how glaucoma affects retinal ganglion cell (RGC) signaling to the dLGN in DBA/2J mice, finding functional deficits linked to intraocular pressure.

This study examines how neuronal and synaptic function in the thalamus changes in mouse glaucoma models, finding age- and IOP-dependent alterations in intrinsic excitability and synaptic currents.

This study examines structural and functional changes in thalamocortical neurons following bilateral enucleation in mice, revealing degeneration and compensatory plasticity.

This study shows that early-stage ocular hypertension causes pre- and post-synaptic functional and structural changes at retinogeniculate synapses before significant RGC loss.