Author

Mélissa Beaudoin

Montreal Heart InstituteORCID 0000-0002-3173-0781Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:CRISPR screen· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Ken Sin LoiD· 3 shared Guillaume LettreiD· 2 shared Abdou MousasiD· 1 shared Adam S. ButterworthiD· 1 shared Adolfo CorreaiD· 1 shared Alan B. ZondermaniD· 1 shared Allan R LinnebergiD· 1 shared Andreas GreinacheriD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersGenomics

Ken Sin LoORCID

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3 papers

Recent·Most cited

Pooled CRISPR screens identify genes and non-coding genomic regions that regulate red blood cell density

Nicolas Brosseau, Thomas Pincez, Ken Sin Lo, Mélissa Beaudoin, Guillaume Lettre

The paper uses CRISPR screens to identify genes and non-coding regions affecting red blood cell density, finding 17 genes and 13 regions, some novel, that regulate this trait.

bioRxiv · Sep 20, 2025 · PreprintGenomics

CRISPR perturbations at many coronary artery disease loci impair vascular endothelial cell functions

Florian Wünnemann, Thierry Fotsing Tadjo, Mélissa Beaudoin, Simon Lalonde, Ken Sin Lo, Benjamin P. Kleinstiver, Guillaume Lettre

The paper assesses the impact of CRISPR perturbations on vascular endothelial cell functions at CAD loci, identifying variants that significantly affect endothelial phenotypes.

PLoS Genetics · Mar 16, 2023Peer-reviewedGenomics

Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

Ming‐Huei Chen, Laura M. Raffield, Abdou Mousas, Saori Sakaue, Jennifer E. Huffman, Arden Moscati, Bhavi Trivedi, Tao Jiang, Parsa Akbari, Dragana Vuckovic, Erik L. Bao, Xue Yun Zhong, Regina Manansala, Véronique Laplante, Minhui Chen, , Ruth J. F. Loos

This study identifies 5,552 blood-cell trait-variant associations across 746,667 individuals from 5 global populations, including 71 novel loci and ancestry-specific variants not found in European ancestry populations.

Cell · Sep 1, 2020Peer-reviewedGenetics