Author

Sophie Hall

University of BristolORCID 0000-0002-3176-6004Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Alastair W. PooleiD· 3 shared B. O. RandiD· 3 shared Christiane SchaffitzeliD· 3 shared Dakang SheniD· 3 shared Iara Aimê CardosoiD· 3 shared Imre BergeriD· 3 shared Mark C. WilkinsoniD· 3 shared Nicholas R. CasewelliD· 3 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Alastair W. PooleORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Recombinant Echis disintegrins reveal distinct inhibitory profiles on platelet aggregation and endothelial cell migration

Iara Aimê Cardoso, Sophie Hall, Thomas Crasset, Mark C. Wilkinson, Adam Robinson, B. O. Rand, Dakang Shen, Connor Webb, R.D. Stenner, David Waterhouse, Ingeborg Hers, Renaud Vincentelli, Imre Berger, Nicholas R. Casewell, Loïc Quinton, , Christiane Schaffitzel

This study characterizes recombinant disintegrins from Echis species, showing distinct inhibitory effects on platelet aggregation and endothelial cell migration.

bioRxiv · Sep 10, 2026 · PreprintBiochemistry

Disintegrin-like and Cysteine-rich Domains Govern Enzymatic Activity and Substrate Recognition in Echis Snake Venom Metalloproteinases

Sophie Hall, B. O. Rand, Iara Aimê Cardoso, Adam Robinson, Mark C. Wilkinson, Dakang Shen, Sebastían Fernández, Georgia Balchin, Konrad K. Hus, Alastair W. Poole, Nicholas R. Casewell, Imre Berger, Christiane Schaffitzel

This study investigates the roles of disintegrin-like and cysteine-rich domains in substrate recognition and catalytic activity of PIII snake venom metalloproteinases using recombinant variants and functional assays.

bioRxiv · Aug 27, 2026 · PreprintBiochemistry

Purified Zymogens Reveal Mechanisms of Snake Venom Metalloproteinase Auto-Activation

Sophie Hall, Iara Aimê Cardoso, Mark C. Wilkinson, Maria Molina Carretero, Srikanth Lingappa, B. O. Rand, Dakang Shen, Johara Boldrini-França, Richard Stenner, Stefanie K. Menzies, Georgia Balchin, Konrad K. Hus, Renaud Vincentelli, Andrew David Mumford, Alastair W. Poole, , Christiane Schaffitzel

The paper develops a method to produce and activate purified snake venom metalloproteinases (SVMPs) using recombinant zymogens, enabling detailed biochemical and functional analysis.

eLife · Jun 2, 2026Peer-reviewedBiochemistry