Imre Berger

This study analyzes the structural heterogeneity of uncrosslinked FtsH-HflKC complexes using cryo-EM and SAXS, revealing variable FtsH occupancy and a distinct wild-type FtsH architecture.

This study characterizes recombinant disintegrins from Echis species, showing distinct inhibitory effects on platelet aggregation and endothelial cell migration.

This study investigates the roles of disintegrin-like and cysteine-rich domains in substrate recognition and catalytic activity of PIII snake venom metalloproteinases using recombinant variants and functional assays.

The paper develops a method to produce and activate purified snake venom metalloproteinases (SVMPs) using recombinant zymogens, enabling detailed biochemical and functional analysis.

The paper reports cryo-EM structures of the Escherichia coli FtsH periplasmic domain, revealing conformational flexibility and its role in substrate translocation.

This study uses D-NEMD simulations to show how pH changes induce variant-specific conformational changes in SARS-CoV-2 spike proteins, affecting their stability and entry mechanisms.

This study identifies UPF2's RNA-binding and unfolding activities, showing its role in stabilizing single-stranded RNA and supporting NMD factor interactions.

The paper engineers ADDobody protein scaffolds to generate high-avidity ADDomer super-binders through genetic modification and structural validation.

This study shows that ATAC and SAGA HAT modules enhance transcription factor binding to nucleosomes without requiring histone acetylation.

This paper develops a baculovirus-based system for delivering large DNA cargoes for CRISPR-based genome editing in human cells, achieving up to 30% correct interventions.

The study identifies specific TAF8 regions critical for TFIID lobe B assembly and TAF2 interactions, showing their necessity for mouse embryonic stem cell survival.

This study investigates how the BriS{Delta} variant of SARS-CoV-2 affects spike structure, function, and infectivity across different cell types.

The paper shows that the TBPL2/TFIIA complex establishes the oocyte transcriptome by using a specific TSS recognition code through oocyte-specific promoter usage.