Stefanie K. Menzies

Repurposed small molecule toxin inhibitors neutralise a diversity of venoms from the Neotropical viperid snake genus Bothrops

This study evaluates repurposed drugs against venoms from the Bothrops snake genus, finding that metalloproteinase inhibitors effectively neutralize multiple venom effects.

Purified Zymogens Reveal Mechanisms of Snake Venom Metalloproteinase Auto-Activation

The paper develops a method to produce and activate purified snake venom metalloproteinases (SVMPs) using recombinant zymogens, enabling detailed biochemical and functional analysis.

A drug combinational therapy consisting of toxin phospholipase A2 and metalloproteinase inhibitors provides preclinical protection against North American Crotalid snakebite envenoming

This study evaluates drug combinations to treat snakebite envenoming, finding that combining SVMP and PLA2 inhibitors provides broad protection against lethal effects.