Author

Kathleen T. Xie

Novartis Biomedical ResearchORCID 0000-0002-3178-8959Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Alexander A. Pollen· 1 shared Alyssa M Yoxsimer· 1 shared Alyssa Synan· 1 shared Andrew R. GreeniD· 1 shared Anthony S. Malamas· 1 shared Bjarni Jónsson· 1 shared Claude Logel· 1 shared Craig B. LoweiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperEvolutionary Biology

Alexander A. Pollen

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Rapid and repeated evolution of myosin copy number in threespine stickleback

Alyssa M Yoxsimer, Rhea R. Daugherty, Emily E. Hare, Yingguang Frank Chan, Felicity C. Jones, Garrett A. Roberts Kingman, Emma Offenberg, Timothy R. Howes, Haili Zhang, Alexander A. Pollen, Shannon D. Brady, Kathleen T. Xie, Heidi I. Chen, Craig B. Lowe, Eric H. Au, , David M. Kingsley

The paper shows that freshwater threespine stickleback fish have evolved expanded copies of the MYH3C gene family, which is linked to muscle development and adaptive divergence from marine populations.

Current Biology · Mar 24, 2026Peer-reviewedEvolutionary Biology

A bispecific antibody-drug conjugate targeting pCAD and CDH17 has antitumor activity and improved tumor specificity

Alyssa Synan, Nila C. Wu, Roberto Velazquez, Thomas G. Gesner, Claude Logel, Kathrin Mueller, Andrew R. Green, Patrizia Barzaghi-Rinaudo, Quincey Simmons, Samuele Mercan, Xingyi Shi, Xun Li, Vivek Sagar, Joshua M. Korn, Margaret E. McLaughlin, , Joseph A. D’Alessio

This study develops a bispecific antibody-drug conjugate targeting pCAD and CDH17, showing antitumor activity in dual antigen-expressing tumors but not in single antigen-expressing tumors.

mAbs · Jan 6, 2025Peer-reviewedCancer Biology