Enterococcal Polysaccharide Antigen (EPA) rhamnan backbone contributes to cell wall architecture and is essential for antimicrobial resistance, innate immune evasion and phage infection
Lea Kupcova, Nishan Nathoo, Bartosz J. Michno…·Stéphane Mesnage
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University of SheffieldORCID 0000-0002-3179-0098Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Lea Kupcova, Nishan Nathoo, Bartosz J. Michno…·Stéphane Mesnage
Robert E Smith, Bartosz J. Michno, Lowrence Rene Christena…·Stéphane Mesnage
This paper identifies AtlE, an N-acetylmuramidase essential for virulence in E. faecalis, showing its role in cell wall remodelling and immune evasion via the release of EPA-containing fragments.
Jessica L. Davis, Joshua S Norwood, Robert E. Smith…·Stéphane Mesnage
This study determines the structure of the Enterococcal Polysaccharide Antigen (EPA) from E. faecalis and explores its role in immune evasion and phage susceptibility.
Joshua S Norwood, Jessica L. Davis, Bartłomiej Salamaga…·Stéphane Mesnage
This study develops an in vitro assay to investigate how EPA decorations on E. faecalis affect phagocytosis, showing that decoration deletion increases phagocytosis and that lipoproteins are not involved.