Peter J. Rohweder

The paper identifies a conserved loop in herpesvirus proteases that controls dimerization and enzyme activity, presenting a new target for antiviral inhibitors.

The paper identifies LyLAP as a key enzyme for lysosomal degradation of transmembrane proteins, showing its role in maintaining endocytic activity and lysosomal stability in pancreatic cancer.

The paper uses deep mutational scanning to explore how chemical perturbations affect ubiquitin's mutational tolerance, revealing sensitization of most positions except two.