Author

Isaac P. Heremans

de Duve InstituteORCID 0000-0001-6339-4367Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:proteomics· 1

Frequent Co-Authors

Guido T. BommeriD· 2 shared Aakriti JainiD· 1 shared Anabelle DecottigniesiD· 1 shared Barbara MathieuiD· 1 shared Bénédicte BrichardiD· 1 shared Bernard GalleziD· 1 shared Charles S. CraikiD· 1 shared Cyril CorbetiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Guido T. BommerORCID

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2 papers

Recent·Most cited

Human mitochondrial DNA variants influence telomere length: evidence from a transmitochondrial cybrid model

Manon Mahieu, Jean‐Philippe Defour, Barbara Mathieu, Elena Richiardone, Isaac P. Heremans, Elisa Fabiole, Gabriel Levy, Gabriel Le Berre, Isabelle Scheers, Bénédicte Brichard, Thierry Arnould, Patrick Revy, Guido T. Bommer, Bernard Gallez, Cyril Corbet, Anabelle Decottignies

The paper investigates how mitochondrial DNA variants affect telomere length using transmitochondrial cybrids, finding an inverse correlation between donor telomere length and mitochondrial ROS levels.

bioRxiv · Jun 27, 2025 · PreprintCell Biology

Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins

Aakriti Jain, Isaac P. Heremans, Gilles Rademaker, Tyler C. Detomasi, Peter J. Rohweder, Dashiell Anderson, Justin Zhang, Grace A. Hernandez, Suprit Gupta, Teresa von Linde, Mike Lange, Martina Spacci, Jiayi Luo, Y. Rose Citron, James A. Olzmann, , Roberto Zoncu

The paper identifies LyLAP as a key enzyme for lysosomal degradation of transmembrane proteins, showing its role in maintaining endocytic activity and lysosomal stability in pancreatic cancer.

Science · Mar 27, 2025Peer-reviewedBiochemistry