Nuclear Expression and DNA Binding Capacity of Receptor for Advanced Glycation End Products in Renal Tissue
Brooke E. Harcourt, Aaron McClelland, Hiroshi Yamamoto, Hideto Yonekura, Yasuhiko Yamamoto, Sally A. Penfold, Amelia K. Fotheringham, David Alan Vesey, David Wayne Johnson, Melinda T. Coughlan, Mark Emmanuel Cooper, Phillip Kantharidis, Josephine Maree Forbes
The paper identifies a nuclear RAGE isoform in kidney tissue that binds to its own gene promoter, suggesting self-regulation of RAGE expression, which is altered in obesity and kidney disease.
bioRxiv · May 9, 2019 · PreprintMolecular Biology