Author

Andrej Kováč

Slovak Academy of SciencesORCID 0000-0002-3223-8705Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:rat· 3 Assay:metabolomics· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Petra MajerováiD· 4 shared Dominika OlešováiD· 3 shared Juraj PiešťanskýiD· 3 shared Alena MichalicováiD· 2 shared Jozef HanesiD· 2 shared Jozef Vegh· 2 shared Aleš KvasničkaiD· 1 shared Dana DobešováiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersNeuroscience

Petra MajerováORCID

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4 papers

Recent·Most cited

Kynurenine pathway metabolomics in heatstroke: a validated LC-MS/MS method reveals compartment-specific neurochemical disruption in a murine model.

Petra Majerová, Dorothy Wasike, Juraj Piešťanský, Andrej Kováč

The paper uses LC-MS/MS to analyze kynurenine pathway metabolites in plasma and brain tissue of heatstroke mice, revealing compartment-specific metabolic changes and potential biomarkers.

bioRxiv · Jul 3, 2026 · PreprintNeuroscience

Changes in lipid metabolism track with the progression of neurofibrillary pathology in tauopathies.

Dominika Olešová, Dana Dobešová, Petra Majerová, Radana Brumarová, Aleš Kvasnička, Štěpán Kouřil, Eva Stevens, Jozef Hanes, Ľubica Fialová, Alena Michalicová, Juraj Piešťanský, Jakub Šinský, Petr Kaňovský, David Friedecký, Andrej Kováč

The paper shows that lipid metabolism changes with tauopathy progression, linking pathological tau to altered lipid production and microglial lipid droplet accumulation.

Journal of Neuroinflammation · Mar 27, 2024Peer-reviewedNeuroscience

Development of blood-cerebrospinal fluid barrier model expressing pharmaceutically important transporters.

Petra Majerová, Krutika Khiratkar, Kevin James, Dominika Olešová, Jozef Vegh, Andrej Kováč

The paper develops a blood-cerebrospinal fluid barrier model from rat choroid plexus epithelial cells that exhibits functional tight junctions and expresses key transporters for drug discovery.

bioRxiv · Jan 22, 2024 · PreprintNeuroscience

Analog of Kynurenic Acid Decreases Tau Pathology by Modulating Astrogliosis in Rat Model for Tauopathy.

Petra Majerová, Dominika Olešová, Greta Golisova, Martina Buralova, Alena Michalicová, Jozef Vegh, Juraj Piešťanský, Mangesh Ramesh Bhide, Jozef Hanes, Andrej Kováč

This study shows that chronic administration of KYNA-1, a kynurenic acid analog, reduces tau hyperphosphorylation and neuroinflammation in a tau transgenic rat model.

Biomedicine & Pharmacotherapy · Jun 13, 2022Peer-reviewedNeuroscience