Dominika Olešová

This study uses multimodal metabolic analysis to detect early metabolic changes in acute neuroinflammation, showing reduced pyruvate metabolism and ongoing inflammation without structural MRI changes.

The paper shows that lipid metabolism changes with tauopathy progression, linking pathological tau to altered lipid production and microglial lipid droplet accumulation.

The paper develops a blood-cerebrospinal fluid barrier model from rat choroid plexus epithelial cells that exhibits functional tight junctions and expresses key transporters for drug discovery.

This study shows that chronic administration of KYNA-1, a kynurenic acid analog, reduces tau hyperphosphorylation and neuroinflammation in a tau transgenic rat model.