Gonçalo J. L. Bernardes

LuxSit Pro and sPro: Next-Generation Designed Luciferases for Bioluminescent Reporting and Complementation-Based Detection

The paper introduces LuxSit Pro and sPro, next-generation luciferases with enhanced brightness, stability, and versatility for bioluminescent reporting and molecular interaction detection.

Bifunctional Phagocytic Synapse Enhancers for Cancer Immunotherapy

This paper introduces PSEs, bifunctional molecules that enhance phagocytosis and block PD-L1, showing improved antitumor responses in animal models.

Designed Endocytosis-Triggering Proteins mediate Targeted Degradation and amplify signaling

The paper designs EndoTags to trigger endocytosis and degradation of target proteins, enabling tissue-specific targeting and therapeutic applications.

Fragment-based computational design of antibodies targeting structured epitopes

A fragment-based computational method designs nanobodies targeting specific epitopes with nanomolar affinities, without requiring high-resolution antigen structures.