Alexander David Noblett

Ovarian support cell in vitro maturation (OSC-IVM) results in healthy murine live births with no evidence of reprotoxicology in a multigenerational study

This study shows that using human stem cell-derived ovarian support cells for in vitro maturation in mice leads to healthy live births without reprotoxic effects across generations.

Reproducible differentiation of pure ovarian support cells from clinical-grade hiPSCs as a novel infertility treatment

The paper describes the development of a clinical-grade hiPSC-derived ovarian support cell protocol to improve in vitro maturation of oocytes and embryo formation.

Human induced pluripotent stem cell-derived ovarian support cell co-culture improves oocyte maturation in vitro after abbreviated gonadotropin stimulation

This study shows that co-culturing human oocytes with ovarian support cells improves in vitro maturation rates and blastocyst formation compared to standard IVM methods.

Improved rescue of immature oocytes obtained from conventional gonadotropin stimulation cycles via human induced pluripotent stem cell-derived ovarian support cell co-culture

This study shows that co-culturing immature human oocytes with hiPSC-derived ovarian support cells improves in vitro maturation rates and transcriptomic similarity to in vivo matured oocytes.