Merrick Pierson Smela

SeqVerify is a computational pipeline that analyzes whole genome sequencing data to verify gene editing outcomes and detect abnormalities in cell lines.

This study develops a method to induce meiosis from human pluripotent stem cells, showing key meiotic stages and gene expression similar to in vivo oogonia.

This study shows that co-culturing human oocytes with ovarian support cells improves in vitro maturation rates and blastocyst formation compared to standard IVM methods.

This study shows that co-culturing immature human oocytes with hiPSC-derived ovarian support cells improves in vitro maturation rates and transcriptomic similarity to in vivo matured oocytes.

This study generates functional ovarian granulosa-like cells from human iPSCs by overexpressing NR5A1 and RUNX1 or RUNX2, enabling the formation of ovary-like organoids with germ cells.

This study identifies key transcription factors that drive the rapid differentiation of human induced pluripotent stem cells into oogonia-like cells using a combinatorial approach and computational tools.

TBDB provides a database of structurally annotated T-box riboswitch-tRNA pairs, offering the largest collection of sequence and structural annotations for this regulatory RNA family.

This study shows PRDM14 is essential for human PGC fate, contradicting previous findings, and reveals divergent regulatory mechanisms between human and mouse PGCs using inducible degrons.