Christian Clark Kramme

This study shows that using human stem cell-derived ovarian support cells for in vitro maturation in mice leads to healthy live births without reprotoxic effects across generations.

The paper describes the development of a clinical-grade hiPSC-derived ovarian support cell protocol to improve in vitro maturation of oocytes and embryo formation.

This study shows that co-culturing human oocytes with ovarian support cells improves in vitro maturation rates and blastocyst formation compared to standard IVM methods.

This study shows that co-culturing immature human oocytes with hiPSC-derived ovarian support cells improves in vitro maturation rates and transcriptomic similarity to in vivo matured oocytes.

This study generates functional ovarian granulosa-like cells from human iPSCs by overexpressing NR5A1 and RUNX1 or RUNX2, enabling the formation of ovary-like organoids with germ cells.

This study identifies key transcription factors that drive the rapid differentiation of human induced pluripotent stem cells into oogonia-like cells using a combinatorial approach and computational tools.