Ikuko T. Smith

Disrupted Brain Organoid Circuitry, Structural Organization, and Spine Morphology in 7q11.23 Copy Number Variant Syndromes

This study investigates how 7q11.23 copy number variations disrupt brain organoid development, showing structural and functional abnormalities in neural circuits and spine morphology.

Functional and structural characterization of dendritic spine pathology in a mouse model of tauopathy

The paper examines how tauopathy affects dendritic spine function and structure in mice, finding that spines in tau mutants are hypoactive and less tuned compared to controls.

The Cousa objective: a long working distance air objective for multiphoton imaging in vivo

The paper introduces a long working distance air objective for multiphoton imaging in vivo, demonstrating its performance across multiple species and imaging systems.

Mesoscale functional architecture in medial posterior parietal cortex

The paper identifies two distinct functional modules in the medial posterior parietal cortex of mice, each with unique roles in integrating sensory and cognitive information versus transmitting movement and memory-related signals.

The impact of interneurons on nonlinear synaptic integration in the neocortex

This study investigates how two types of interneurons modulate nonlinear synaptic integration in mouse visual cortex, finding that SOM interneurons reduce response amplitude while PV interneurons have minimal effects.

Mice use robust and common strategies to discriminate natural scenes

This study shows mice use common strategies to discriminate natural scenes, with performance predicted by a simple V1-inspired model.

Wide field-of-view, twin-region two-photon imaging across extended cortical networks

The paper introduces a two-photon imaging system with a wide field-of-view and uses it to measure neuron activity correlations in awake mice.