Author

K. Sharp

Brighton and Sussex Medical SchoolORCID 0000-0002-3243-7050Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

K. Sharp3 papers

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Aimilia VareliiD· 1 shared Amarpreet DeviiD· 1 shared Andrea G. S. PepperiD· 1 shared Chris J. PepperiD· 1 shared David M. RossiD· 1 shared Eleni E LadikouiD· 1 shared Emma KennedyiD· 1 shared Fabio A. SimoesiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

Aimilia VareliORCID

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2 papers

Recent·Most cited

The Lysis Cassette of Jumbophage phiKZ

Prasanth Manohar, Joshua Wan, Gabriella Ganser, K. Sharp, Ry Young

The paper identifies a lysis cassette in phiKZ phage essential for temporally regulated host envelope disruption, including a novel cytoplasmic regulator interacting with the holin.

Scientific Reports · Jan 20, 2026Peer-reviewedMicrobiology

A novel in-vitro model of the bone marrow microenvironment in AML identifies CD44 and Focal Adhesion Kinase as therapeutic targets to reverse cell adhesion-mediated drug resistance

Eleni E Ladikou, K. Sharp, Fabio A. Simoes, John R Jones, Thomas A. Burley, Lauren Stott, Aimilia Vareli, Emma Kennedy, Sophie Vause, Timothy J. T. Chevassut, Amarpreet Devi, Iona Ashworth, David M. Ross, Tanja Nicole Hartmann, Simon A. Mitchell, , Andrea G. S. Pepper

This study identifies CD44 and FAK as therapeutic targets to reverse adhesion-mediated drug resistance in AML by developing an in-vitro BMME model and testing their synergistic effects.

Cancers · Jan 3, 2025Peer-reviewedCancer Biology