This study identifies caspase-7 as responsible for early-peaking caspase activity at the plasma membrane during apoptosis, which drives phosphatidylserine exposure and efferocytosis.

bioRxiv · Mar 17, 2025 · PreprintCell Biology

Cas9-mediated Genome Editing Reveals a Significant Contribution of Calcium Signaling Pathways to Anhydrobiosis in Pv11

Yugo Miyata, Hiroto Fuse, Shoko Tokumoto, Yusuke Hiki, Ruslan M. Deviatiiarov, Yuki Yoshida, Takahiro Yamada, Richard Cornette, Oleg Gusev, Elena Ilyasovna Shagimardanova, Akira Funahashi, Takahiro Kikawada

The paper uses genome editing to show that calcium signaling pathways, specifically calmodulin-calcineurin-NFAT and calmodulin-calmodulin kinase-CREB, play distinct roles in anhydrobiosis in Pv11 cells.

Scientific Reports · Oct 5, 2021Peer-reviewedMolecular Biology

Intracellular localization and gene expression analysis provide new insights on LEA proteins diversity in anhydrobiotic midge

Sabina A. Kondratyeva, Alexander A. Nesmelov, Alexander V. Cherkasov, Yugo Miyata, Shoko Tokumoto, Takahiro Kikawada, Oleg Gusev, Elena Ilyasovna Shagimardanova

The paper analyzes LEA protein expression and localization in anhydrobiotic midge cells to understand their role in desiccation tolerance.

bioRxiv · Oct 30, 2019 · PreprintMolecular Biology