Oleg Gusev

This study investigates how CTCF's functional properties evolved across bilaterian species, revealing gradual changes in its ability to regulate chromatin structure and transcription.

This paper presents the first chromosome-level genome assembly of the sponge Halisarca dujardinii, along with mitochondrial genome and comprehensive annotation.

The paper creates a promoterome and proteome atlas of human skeletal muscles, revealing molecular diversity and identifying key transcription factors and genetic variants associated with muscle traits.

The paper predicts and annotates alternative transcription starts and promoter shifts in the chicken genome using CAGE data, revealing that housekeeping genes may use single sharp promoters and undergo significant promoter shifts.

This study adapts the ACME HS method to isolate intact single cells from fresh-frozen endocrine tissues, showing it preserves cell integrity and gene expression better than other methods.

FLIC reconstructs full-length isoforms from long-read data, outperforming existing tools and matching CAGE accuracy while being more efficient.

The paper uses genome editing to show that calcium signaling pathways, specifically calmodulin-calcineurin-NFAT and calmodulin-calmodulin kinase-CREB, play distinct roles in anhydrobiosis in Pv11 cells.

The paper identifies regulatory modules controlling dog color patterns and shows their evolutionary origin in extinct canids.

The paper presents a comprehensive CAGE atlas of human cardiac promoters and enhancers, identifying novel regulatory elements and their association with heart morphology and pathologies.

The paper analyzes LEA protein expression and localization in anhydrobiotic midge cells to understand their role in desiccation tolerance.

This study uses CAGE-seq to analyze transcriptome changes in Pv11 cells during desiccation and rehydration, identifying DEGs and suggesting DNA repair as a recovery mechanism.