Krishnan Padmanabhan

Adult-neurogenesis allows for representational stability and flexibility in early olfactory system

This study shows adult-neurogenesis supports both stable and flexible odor representations in the olfactory system through experience-dependent mechanisms in different brain regions.

Projection-Specific Intersectional Optogenetics for Precise Excitation and Inhibition in the Marmoset Brain

The paper develops an optogenetic method to selectively excite and inhibit projection-specific neurons in marmosets, enabling precise modulation of neural circuits.

Differential disruptions in population coding along the dorsal-ventral axis of CA1 in the APP/PS1 mouse model of Aβ pathology

The paper investigates how Aβ pathology affects neural activity patterns in dorsal and ventral CA1 regions of the hippocampus in APP/PS1 mice, finding distinct disruptions in population coding between the two regions.

Network size affects the complexity of activity in human iPSC-derived neuronal populations

The paper investigates how network size affects neural activity dynamics in human iPSC-derived neuronal cultures, finding that varying neuron densities alters both individual cell properties and collective network behavior.

Top-down feedback enables flexible coding strategies in olfactory cortex

The paper demonstrates that top-down feedback to the olfactory bulb allows the olfactory cortex to switch between temporal and combinatorial coding strategies, improving odor discrimination performance.

Divergence in Population Coding for Space between Dorsal and Ventral CA1

The paper compares population coding strategies for space in dorsal and ventral CA1 of mice, finding differences in dimensionality, information content, and model predictability.

Changes in weak pair-wise correlations during running reshapes network state in the main olfactory bulb

The paper shows that running in mice changes spontaneous neural activity in the olfactory bulb, increasing population entropy and suggesting higher-order neuron interactions during locomotion.

Top-down Control of Inhibition Reshapes Neural Dynamics Giving Rise to a Diversity of Computations

The paper uses a rate model to show that top-down feedback to inhibitory neurons generates diverse network dynamics and supports computations like pattern separation and gamma oscillations.

Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer’s disease

The paper examines how Aβ accumulation in the APP/PS1 mouse model affects neural ensemble coding capacity in the dorsal CA1 region, finding reduced entropy and coding capacity.

Sex Differences in Head-fixed Running Behavior

This study identifies sex differences in head-fixed running behavior in mice, showing females run forward faster than males, which could inform neural studies of behavior.