Discovery of two structurally distinct classes of inhibitors targeting the nuclease MUS81 and enhancing efficacy of chemotherapy in cancer cells
Jana Prochazkova, Benoît Carbain, Victoria Marini, Fedor Nikulenkov, Štěpán Havel, Naresh Akavaram, Prashant Khirsariya, Alexandra Sisáková, Jakub Cibulka, Michala Boudova, Magdalena Zacpalova, Magdalena Kalovska, Joana Rodrigues, Lukáš Daniel, Jan Brezovský, , Lumír Krejčí
This paper identifies two distinct MUS81 inhibitors that enhance chemotherapy efficacy by impairing DNA repair in cancer cells.
Journal of Medicinal Chemistry · Feb 25, 2026Peer-reviewedMolecular Biology