Claus M. Azzalin

Molecular and functional characterization of telomeric repeat-containing RNAs in Chinese hamster ovary cells

This study characterizes TERRA and ARIA telomeric RNAs in CHO cells, showing ARIA regulates telomeric DNA integrity by preventing ssDNA formation at ITSs.

Discovery of two structurally distinct classes of inhibitors targeting the nuclease MUS81 and enhancing efficacy of chemotherapy in cancer cells

This paper identifies two distinct MUS81 inhibitors that enhance chemotherapy efficacy by impairing DNA repair in cancer cells.

Human PC4 supports telomere stability and viability in cells utilizing the alternative lengthening of telomeres mechanism

The paper identifies PC4 as a novel factor essential for ALT cell viability, showing that its depletion causes ALT cell death and telomere fragility.

Epigenetic reprogramming by TET enzymes impacts co-transcriptional R-loops

This study shows that TET enzyme-mediated 5hmC formation promotes R-loop formation during transcription in stem cells, affecting gene expression.

Genome-wide chromosomal association of Upf1 is linked to Pol II transcription in Schizosaccharomyces pombe

This paper reports genome-wide ChIP data showing Upf1 associates with active genes in S. pombe, correlating with Pol II transcription and mRNA levels, and reveals transcriptional defects in Upf1-deficient cells.

RNA-DNA hybrids support recombination-based telomere maintenance in fission yeast

This study investigates telomere maintenance in fission yeast lacking telomerase, showing that TERRA RNA and shelterin component changes support recombination-based telomere maintenance.