The paper imputes transcriptional patterns from ancient genomes to identify molecular targets of selection over 10,000 years of Western Eurasian history.

bioRxiv · Nov 21, 2025 · PreprintGenomics

Resolving out of Africa event for Papua New Guinean population using neural network

Mayukh Mondal, Mathilde André, Ajai Kumar Pathak, Nicolas Brucato, François‐Xavier Ricaut, Mait Metspalu, Anders Eriksson

This study uses neural networks to analyze genetic data from Papua New Guinean populations, finding a bottleneck and slower growth rate rather than admixture with an early out of Africa population.

Nature Communications · Jul 9, 2025Peer-reviewedGenetics

Exploring the molecular basis of the genetic correlation between body mass index and brain morphological traits

Daniela Fusco, Camilla Marinelli, Mathilde André, Lucia Troiani, Martina Noè, Fabrizio Pizzagalli, Davide Marnetto, Paolo Provero

The paper computes genetic correlations between BMI and brain morphology traits using UK Biobank data and identifies molecular mechanisms through eQTL and Mendelian randomization.

PLoS Genetics · Apr 10, 2025Peer-reviewedGenetic & Genomic Medicine

Denisovan admixture facilitated environmental adaptation in Papua New Guinean populations

Danat Yermakovich, Mathilde André, Nicolas Brucato, Jason Kariwiga, Matthew Leavesley, Vasili Pankratov, Mayukh Mondal, François‐Xavier Ricaut, Michael Dannemann

This study examines Denisovan and Neandertal DNA distribution in Papua New Guinean populations, finding that Denisovan-like haplotypes are associated with brain development and immune response genes, suggesting adaptive significance.

Proceedings of the National Academy of Sciences · Jun 18, 2024Peer-reviewedGenomics