Michael Dannemann

Gene-environment interaction loci with signatures of mid- to late Holocene selection show evidence for diet-dependent genetic effects

The paper identifies gene-environment interaction loci showing signs of selection and diet-dependent genetic effects across human populations.

Massively parallel characterization reveals context-dependent and non-additive regulatory effects of closely spaced variant pairs

The paper uses a massively parallel reporter assay to study the regulatory effects of variant pairs in enhancers, finding non-additive effects and context-dependent interactions.

Using sequence-to-function models to interpret archaic hominin introgression

The paper uses sequence-to-function models to predict the functional impact of archaic hominin introgression in Papuan individuals, identifying genes associated with introgressed haplotypes.

Mapping the gene regulatory landscape of archaic hominin introgression in modern Papuans

The paper investigates the regulatory effects of Neanderthal and Denisovan introgression in Papuan populations using a massively parallel reporter assay, finding differential activity in immune-related genes.

Denisovan admixture facilitated environmental adaptation in Papua New Guinean populations

This study examines Denisovan and Neandertal DNA distribution in Papua New Guinean populations, finding that Denisovan-like haplotypes are associated with brain development and immune response genes, suggesting adaptive significance.

Long-range regulatory effects of Neandertal DNA in modern humans

This study identifies Neandertal DNA's long-range regulatory effects on gene expression in modern humans, showing their influence on immune traits, schizophrenia, and other phenotypes.

Cell atlas of the regenerating human liver after portal vein embolization

This study uses single-cell transcriptomics to analyze liver regeneration after portal vein embolization, identifying changes in cell states and immune interactions.

Detecting ancient positive selection in humans using extended lineage sorting

This study detects ancient positive selection in humans by identifying genomic regions where Neandertals and Denisovans fall outside present-day human variation, finding evidence for regulatory changes associated with human-specific traits.