Daniela Fusco

Sex-related signatures in the plasma proteome not attributable to XX and XY chromosomes and their impact on health and disease

The paper introduces the Proteomic Sex Index (PSI), a continuous measure of plasma proteome alignment with chromosomal sex, showing its association with health and disease traits.

Co-expression-based models improve eQTL predictions and highlightnovel transcriptome-wide genes associated with schizophrenia

The paper introduces co-expression-based models to improve eQTL predictions and identifies novel schizophrenia-associated genes using brain RNA-seq data.

Removing genetic effects on plasma proteins enhances their utility as disease biomarkers

The paper removes genetic effects from plasma proteins to enhance their utility as disease biomarkers, showing improved associations with diseases and environmental factors.

Exploring the molecular basis of the genetic correlation between body mass index and brain morphological traits

The paper computes genetic correlations between BMI and brain morphology traits using UK Biobank data and identifies molecular mechanisms through eQTL and Mendelian randomization.

Ancestral genetic components are consistently associated with the complex trait landscape in European biobanks

This study investigates the association between ancestral genetic components and complex traits in European biobanks, finding that these components contribute to trait variation and act as confounders.

Sequence composition and conservation predict the phenotypic relevance of transposable elements

The paper shows that TE sequence and conservation features predict their phenotypic relevance, with ERV1 TEs being an exception due to their unique role in environmental interactions.