Davide Marnetto

Effects of introgressed Neanderthal alleles on present-day brain morphology

The paper examines the effects of Neanderthal introgressed alleles on brain morphology and neuropsychiatric traits using UK Biobank data, identifying associations with specific brain regions and mental health outcomes.

The Neanderthal population history and the introgression landscape inferred from the UK Biobank

The paper uses UK Biobank data to infer Neanderthal population history and introgression patterns, finding divergence times, effective population sizes, and regions of selection.

Co-expression-based models improve eQTL predictions and highlightnovel transcriptome-wide genes associated with schizophrenia

The paper introduces co-expression-based models to improve eQTL predictions and identifies novel schizophrenia-associated genes using brain RNA-seq data.

Imputed transcriptional patterns in ancient genomes reveal molecular targets of selection

The paper imputes transcriptional patterns from ancient genomes to identify molecular targets of selection over 10,000 years of Western Eurasian history.

Parental haplotypes reconstruction in up to 440,209 individuals reveals recent assortative mating dynamics

The paper estimates genetic assortative mating using haplotype reconstruction in large biobank cohorts, revealing recent trends in mate choice and its genetic impact.

Exploring the molecular basis of the genetic correlation between body mass index and brain morphological traits

The paper computes genetic correlations between BMI and brain morphology traits using UK Biobank data and identifies molecular mechanisms through eQTL and Mendelian randomization.

Partitioning the genomic journey to becoming Homo sapiens

The paper identifies 56 recent functional variants in modern humans, 24 linked to brain functions and skull morphology, which did not introgress into Neanderthals.

Ancestral genetic components are consistently associated with the complex trait landscape in European biobanks

This study investigates the association between ancestral genetic components and complex traits in European biobanks, finding that these components contribute to trait variation and act as confounders.

Sequence composition and conservation predict the phenotypic relevance of transposable elements

The paper shows that TE sequence and conservation features predict their phenotypic relevance, with ERV1 TEs being an exception due to their unique role in environmental interactions.

Regulatory dissection of the severe COVID-19 risk locus introgressed by Neanderthals

The paper identifies four Neanderthal introgressed alleles on chromosome 3 that may modulate the regulation of CCR1 and CCR5, contributing to severe COVID-19 risk.

Ancestral contributions to contemporary European complex traits

This study connects genetic ancestry from three ancient populations to complex traits in Estonian Biobank samples, finding ancestry-specific contributions to traits like BMI and blood cholesterol.

Continental-scale genomic analysis suggests shared post-admixture adaptation in Americas

The paper identifies shared post-admixture adaptation patterns in the Americas by analyzing genomic data from 6,000 admixed individuals, highlighting regions associated with immune response and disease traits.

Creating Artificial Human Genomes Using Generative Models

This study uses generative models to create artificial human genomes that can improve genetic research without compromising privacy.

The genomic impact of European colonization of the Americas

This study analyzes the genetic impact of European colonization on the Americas using genome-wide data from 12,000 individuals, revealing complex contributions from European, African, and other sources.

Selection on the FADS region in Europeans

The paper identifies targets of selection in the FADS region in Europeans, showing allele frequency changes linked to lipid-related phenotypes and dietary adaptations.

Signatures of archaic adaptive introgression in present-day human populations

The paper identifies regions of adaptive introgression in human populations by analyzing uniquely shared archaic alleles in the 1000 Genomes dataset.