Vasili Pankratov

The paper curates a genome-scale nucleotide diversity panel of non-human primates using ploidy-aware variant calling and multiple-genome alignment.

Across 38 catarrhine subspecies, the population-scaled distribution of fitness effects (DFE) tracks effective population size while the unscaled deleterious DFE appears conserved, with no detectable epistasis.

The paper uses a massively parallel reporter assay to study the regulatory effects of variant pairs in enhancers, finding non-additive effects and context-dependent interactions.

The paper examines genetic contributions to educational attainment and occupational status in Estonia during and after the Soviet era using the Estonian Biobank, finding increased genetic influence in education but not occupation.

The paper examines sex-specific links between education-related genetic factors and fertility, finding stronger negative associations in women and weaker or positive associations in men, independent of educational attainment.

The paper shows that migration behavior in Estonia increases spatial genetic differentiation at trait-associated loci, with educational attainment PGS driving inter-regional differences.

The paper identifies 56 recent functional variants in modern humans, 24 linked to brain functions and skull morphology, which did not introgress into Neanderthals.

The paper reviews the Estonian Biobank's role in advancing genomics research and personalized medicine through its comprehensive data and translational focus.

This study investigates the association between ancestral genetic components and complex traits in European biobanks, finding that these components contribute to trait variation and act as confounders.

This study examines Denisovan and Neandertal DNA distribution in Papua New Guinean populations, finding that Denisovan-like haplotypes are associated with brain development and immune response genes, suggesting adaptive significance.

This study identifies Neandertal DNA's long-range regulatory effects on gene expression in modern humans, showing their influence on immune traits, schizophrenia, and other phenotypes.

The paper identifies candidate SNPs under natural selection in autoimmune disorder risk loci and shows they colocalize with selected variants, suggesting functional relevance and implications for autoimmunity.

This paper uses a deep learning approach to analyze whole-genome sequences and supports the back to Africa model over other hypotheses about human migration.

This study connects genetic ancestry from three ancient populations to complex traits in Estonian Biobank samples, finding ancestry-specific contributions to traits like BMI and blood cholesterol.