Paolo Provero

The paper examines the effects of Neanderthal introgressed alleles on brain morphology and neuropsychiatric traits using UK Biobank data, identifying associations with specific brain regions and mental health outcomes.

The paper imputes transcriptional patterns from ancient genomes to identify molecular targets of selection over 10,000 years of Western Eurasian history.

The paper computes genetic correlations between BMI and brain morphology traits using UK Biobank data and identifies molecular mechanisms through eQTL and Mendelian randomization.

This study investigates the association between ancestral genetic components and complex traits in European biobanks, finding that these components contribute to trait variation and act as confounders.

The paper shows that TE sequence and conservation features predict their phenotypic relevance, with ERV1 TEs being an exception due to their unique role in environmental interactions.

The paper introduces contrast subgraphs to compare gene and protein networks from different conditions or techniques, highlighting altered connectivity modules.

This paper improves transcriptome-wide association studies by predicting gene expression from regulatory sequence composition, leading to new gene-phenotype associations.

The paper identifies genetic variants affecting alternative polyadenylation and shows their enrichment in GWAS hits for immune and neurological disorders.

The paper uses somatic mutation data from cancers to predict genes involved in germline mutations' phenotypic effects, showing their predictive power is independent of germline-based methods.

The paper uses somatic mutation patterns from cancer to predict genes involved in phenotypic abnormalities and genetic diseases, showing their predictive power is independent of germline-based methods.

This paper sonifies ChIP-seq data of histone modifications into musical scores and shows that the resulting music is perceived as more pleasant than randomized signals, with the waveform predicting phenotypic properties like differential gene expression.