Michael Weller

TET CpG sequence context specific DNA demeth-ylation shapes progression of IDH-mutant gliomas

The paper identifies DNA methylation changes during IDH-mutant glioma progression, links them to TET enzyme activity, and develops a methylation-based grading system that outperforms WHO grading.

Evolutionary trajectories of IDH-mutant astrocytoma identify molecular grading markers related to cell cycling

The paper analyzes multi-omics data from IDH-mutant astrocytomas to identify molecular markers of malignant progression linked to cell cycling and DNA methylation changes.

Tumor-initiating genetics and therapy drive divergent molecular evolution in IDH-mutant gliomas

This study identifies genetic changes in IDH-mutant gliomas that correlate with treatment response and tumor evolution using longitudinal genomic data from 206 patient samples.

Onco-fetal protein Nogo-A restricts human and mouse glioma vascularization and growth via VEGF-Notch-hippo-metabolic signaling

This study identifies Nogo-A as an onco-fetal protein that inhibits glioma vascularization and growth through VEGF-Notch-Hippo-metabolic signaling in human and mouse models.

The epigenetic evolution of gliomas is determined by their IDH1 mutation status and treatment regimen

This study analyzes the epigenetic evolution of IDH1-mutant and IDH1-wildtype gliomas under treatment, showing IDHmut tumors undergo epigenomic changes resembling IDHwt tumors, with implications for treatment strategies.

Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability

The paper identifies an epigenetic neural signature in glioblastoma that correlates with poor prognosis and therapeutic vulnerability.

Leptomeningeal collaterals regulate reperfusion in ischemic stroke

This study shows that leptomeningeal collaterals regulate reperfusion in ischemic stroke, with poor collaterals leading to hemorrhage and poor outcomes.

Integrated phospho-proteogenomic and single-cell transcriptomic analysis of meningiomas establishes robust subtyping and reveals subtype-specific immune invasion

This study integrates phospho-proteogenomic and single-cell transcriptomic data to subtype meningiomas and identify subtype-specific immune infiltration patterns.

The HLA Ligand Atlas - A resource of natural HLA ligands presented on benign tissues

The paper presents the HLA Ligand Atlas, a resource of HLA-I and -II ligands from benign tissues, showing tissue and individual differences and non-canonical ligand origins.