Author

Sybren L. N. Maas

German Cancer Research CenterORCID 0000-0002-8745-4405Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Adé la BrzobohatáiD· 1 shared Adelheid Wöhrer· 1 shared Albert JeltschiD· 1 shared Almuth Friederike KessleriD· 1 shared Andreas von DeimlingiD· 1 shared Andreas Wilhelm UnterbergiD· 1 shared Angelo DipasqualeiD· 1 shared Anna Sophie BerghoffiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Adé la BrzobohatáORCID

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2 papers

Recent·Most cited

TET CpG sequence context specific DNA demeth-ylation shapes progression of IDH-mutant gliomas

Youri Hoogstrate, Santoesha A. Ghisai, Levi van Hijfte, Rania Head, Iris J. de Heer, Marta Padovan, Maurice de Wit, Wies Vallentgoed, Angelo Dipasquale, Maarten M.J. Wijnenga, Bas Weenink, Rosa Luning, Sybren L. N. Maas, Adé la Brzobohatá, Michael Weller, , Pim J. French

The paper identifies DNA methylation changes during IDH-mutant glioma progression, links them to TET enzyme activity, and develops a methylation-based grading system that outperforms WHO grading.

Cell Reports Medicine · Mar 1, 2026Peer-reviewedCancer Biology

Tumor-Associated Macrophages in Meningiomas: An Independent Prognostic Factor for Poor Survival Outperforming the Benefits of T cells

Catharina Lotsch, Rolf Warta, Fang Liu, Gerhard Jungwirth, Carmen Rommel, Mandy Barthel, Katrin Lamszus, Almuth Friederike Kessler, Niels Grabe, Mario Loehr, Ralf Ketter, Christian Senft, Sybren L. N. Maas, Philipp Sievers, Manfred Westphal, , Christel C. Herold‐Mende

This study identifies high M2-TAM infiltration as an independent poor survival prognostic factor in meningiomas, overriding the beneficial effect of TILs.

Acta Neuropathologica · Oct 9, 2025Peer-reviewedCancer Biology