TET CpG sequence context specific DNA demeth-ylation shapes progression of IDH-mutant gliomas
Youri Hoogstrate, Santoesha A. Ghisai, Levi van Hijfte, Rania Head, Iris J. de Heer, Marta Padovan, Maurice de Wit, Wies Vallentgoed, Angelo Dipasquale, Maarten M.J. Wijnenga, Bas Weenink, Rosa Luning, Sybren L. N. Maas, Adé la Brzobohatá, Michael Weller, , Pim J. French
The paper identifies DNA methylation changes during IDH-mutant glioma progression, links them to TET enzyme activity, and develops a methylation-based grading system that outperforms WHO grading.
Cell Reports Medicine · Mar 1, 2026Peer-reviewedCancer Biology