Inactivation of necroptosis-promoting protein MLKL creates a therapeutic vulnerability in colorectal cancer cells.
Peijia Jiang, Sandhya Chipurupalli, Byong Hoon Yoo, Xiaoyang Liu, Kirill V. Rosen
This study shows that inhibiting MLKL in colorectal cancer cells enhances their sensitivity to homoharringtonine, a drug that blocks autophagy, by disrupting VPS37A-dependent autophagy and triggering parthanatos.
Cell Death and Disease · Feb 20, 2025Peer-reviewedCancer Biology