Cancer BiologyCell Death and DiseasePeer-reviewed
Inactivation of necroptosis-promoting protein MLKL creates a therapeutic vulnerability in colorectal cancer cells.
Peijia Jiang, Sandhya Chipurupalli, Byong Hoon Yoo…·Kirill V. Rosen
This study shows that inhibiting MLKL in colorectal cancer cells enhances their sensitivity to homoharringtonine, a drug that blocks autophagy, by disrupting VPS37A-dependent autophagy and triggering parthanatos.
11 citations