Author

Yong Wei

Hangzhou Institute of Medicine, Chinese Academy of SciencesORCID 0000-0002-3314-118XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Ailan Lin· 1 shared Bin LiuiD· 1 shared Chulin ShaiD· 1 shared Guoyan LuoiD· 1 shared Haifeng QianiD· 1 shared Hang Hubert YiniD· 1 shared Heng ZhangiD· 1 shared Hong CheniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

Ailan Lin

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedDec 7, 2025

Architecture and mechanism of a dual-enzyme retron system in prokaryotic immunity

Xuzichao Li, Qiuqiu He, Yanan Liu…·Heng Zhang

This study characterizes the Ec78 retron system, revealing its dual-enzyme effector complex and the molecular mechanism of phage clearance through cryo-EM structures and functional analysis.

8 citationstop 5%

bacteria (other)structural biology

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BiochemistryNature CommunicationsPeer-reviewedAug 8, 2024

Blocker-SELEX: A Structure-guided Strategy for Developing Inhibitory Aptamers Disrupting Undruggable Transcription Factor Interactions

Tongqing Li, Xueying Liu, Haifeng Qian…·Weihong Tan

This paper introduces Blocker-SELEX, a structure-guided method to design inhibitory aptamers that disrupt transcription factor interactions, demonstrating efficacy against SCAF4/SCAF8-RNAP2 and WDR5-MYC complexes.

37 citationstop 4%

deep learningexperimental assay

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