Bin Liu

Architecture and mechanism of a dual-enzyme retron system in prokaryotic immunity

This study characterizes the Ec78 retron system, revealing its dual-enzyme effector complex and the molecular mechanism of phage clearance through cryo-EM structures and functional analysis.

A dynamic regulatory interface on SARS-CoV-2 RNA polymerase

This paper reports the cryo-EM structure of a SARS-CoV-2 RdRp complex and identifies a new potential drug target interface for antiviral design.

A general role of zinc binding domain revealed by structures of σ28-dependent transcribing complexes

The paper reveals how σ28-RNA polymerase recognizes DNA promoters through zinc binding domain interactions, enhancing transcription from weak σ4/-35 element promoters.

Visualization of two architectures in class-II CAP-dependent transcription activation

This study reports cryo-EM structures of E. coli class-II CAP-dependent transcription activation complexes, revealing conformational changes in RNAP induced by CAP binding.