Architecture and mechanism of a dual-enzyme retron system in prokaryotic immunity
Xuzichao Li, Qiuqiu He, Yanan Liu, Bin Liu, Zhikun Liu, Hong Chen, Shuqin Zhang, Jie Han, Yingcan Liu, Jie Yang, Hang Hubert Yin, Zhenxi Guo, Yong Wei, Zhiyong Yuan, Hongtao Zhu, Heng Zhang
This study characterizes the Ec78 retron system, revealing its dual-enzyme effector complex and the molecular mechanism of phage clearance through cryo-EM structures and functional analysis.
Nature Communications · Dec 7, 2025Peer-reviewedBiochemistry