Author

Kevin Wilkins

University of California, San FranciscoORCID 0000-0002-3315-7659Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Stephen N. FlooriD· 3 shared Lorenzo CalvielloiD· 2 shared Srivats VenkataramananiD· 2 shared Bao ThaiiD· 1 shared Emanuel WyleriD· 1 shared Jacek KróliD· 1 shared Jezrael L. RevaldeiD· 1 shared Karol Jerzy RogowskiiD· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersMolecular Biology

Stephen N. FloorORCID

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3 papers

Recent·Most cited

Determinants of DDX3X sensitivity uncovered using a helicase activity in translation reporter

Kevin Wilkins, Till Schroeder, Sohyun Gu, Jezrael L. Revalde, Stephen N. Floor

This study identifies DDX3X's role in translation by developing HART, a reporter that measures DDX3X-dependent translational activity and reveals structural and functional determinants of its sensitivity.

RNA · May 2, 2024Peer-reviewedMolecular Biology

DDX3X and DDX3Y are redundant in protein synthesis

Srivats Venkataramanan, Margaret Gadek, Lorenzo Calviello, Kevin Wilkins, Stephen N. Floor

This study shows DDX3X and DDX3Y redundantly regulate translation, with DDX3Y compensating for DDX3X loss in human cells, explaining sex-bias in DDX3X-related diseases.

RNA · Sep 17, 2021Peer-reviewedMolecular Biology

DDX3 depletion represses translation of mRNAs with complex 5' UTRs

Lorenzo Calviello, Srivats Venkataramanan, Karol Jerzy Rogowski, Emanuel Wyler, Kevin Wilkins, Malvika Tejura, Bao Thai, Jacek Król, Witold Filipowicz, Markus Landthaler, Stephen N. Floor

This study identifies mRNAs regulated by DDX3 depletion using ribosome profiling and RNA-seq, showing DDX3 preferentially affects a subset of transcripts with complex 5' UTRs.

Nucleic Acids Research · Apr 8, 2021Peer-reviewedMolecular Biology