Trapped in translocation: Stalling of XPD on a crosslinked DNA substrate
Jochen Kuper, Tamsanqa Tafara Hove, Sarah Maidl, Hermann Neitz, Florian Sauer, Maximilian Kempf, Till Schroeder, E. Greiter, Claudia Höbartner, Caroline Kisker
This study uses cryo-EM to reveal how XPD helicase stalls on interstrand crosslinked DNA, identifies functional residues, and suggests a model for NER bubble formation.
Nature Structural & Molecular Biology · May 28, 2024Peer-reviewedBiochemistry