Srivats Venkataramanan

The paper identifies GC content in coding sequences as a key factor in mRNA stabilization following DDX3X depletion, supported by analysis of RNA-seq data and ENCODE datasets.

This study shows DDX3X and DDX3Y redundantly regulate translation, with DDX3Y compensating for DDX3X loss in human cells, explaining sex-bias in DDX3X-related diseases.

This study identifies mRNAs regulated by DDX3 depletion using ribosome profiling and RNA-seq, showing DDX3 preferentially affects a subset of transcripts with complex 5' UTRs.

The paper shows the Microprocessor complex regulates ribosomal protein synthesis by binding TOP motifs and promoting transcription elongation, linking ribosome biogenesis to cell growth.

Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.

This study identifies DDX3X mutations as causing neurodevelopmental disorders by disrupting RNA metabolism and neurogenesis during fetal cortical development.

This study shows that NRDE2 prevents DNA damage accumulation during mitosis under stress by interacting with monomeric nuclear actin, which is critical for genomic integrity.