Johannes V. Swinnen

This study shows that inhibiting de novo lipogenesis and supplementing with PUFAs suppresses prostate cancer progression by inducing oxidative stress and cell death.

This study identifies mTORC2 as a convergent dependency in lung cancer that stabilizes HIF-1β to drive metabolic adaptation and tumor progression, revealing a therapeutic target in sphingolipid metabolism.

STILL-13C maps lipid metabolic flux in intact human tissues using isotopic labeling and MSI, revealing spatial heterogeneity in lipid pathways and responses to inhibition.

LipoGrid quantifies lipidomic and transcriptomic changes across 143 gene knockouts, revealing gene-lipid relationships and compensatory feedback mechanisms.

This study identifies a lipid-mediated signaling pathway driven by microglia that promotes glioblastoma invasion and shows that targeting this pathway can suppress tumor invasion.

This paper introduces human myelin spheres (MyS) as a model for studying myelination and demyelination, showing their ability to form myelinated neurons and mimic in vivo oligodendrocyte development.

This paper introduces MIMA, a deep learning framework for multi-omics integration and batch correction, which effectively removes batch effects and preserves biological information across modalities.

LipidQMap is an open-source tool for processing quantitative mass spectrometry imaging lipidomics data, enabling accurate and reproducible spatial lipid quantification across MSI platforms.

This study identifies ELOVL6 as a therapeutic target in pancreatic cancer by showing its role in c-MYC-driven lipid metabolism and its impact on chemotherapy efficacy.

The paper identifies club-like cells in the prostate tumor microenvironment that contribute to androgen deprivation therapy resistance through immune suppression.

This study investigates the role of oligodendroglia in Wolfram syndrome using mouse models and iPSC-derived cells, finding preserved oligodendroglia function and suggesting alternative targets for treatment.

This study identifies cis-vaccenic acid as a critical oncogenic factor in prostate cancer, showing it rescues cell viability loss from SCD1 inhibition and promotes growth.

This study identifies defective lipid metabolism in Schwann cells as a cause of CMT1A, showing altered lipid composition and membrane dynamics in mouse models and human iPSC-derived cells.

This study shows that cholesterol in extracellular vesicles from repair macrophages enhances remyelination by promoting oligodendrocyte precursor cell differentiation.