Chiara Pastrello

Galectin-1 Modulates Cell Adhesions, Caveolae, and Vascular Permeability in Kidney Endothelial Cells -- Insights from Proteomics, Phosphoproteomics, and Functional Studies

This study shows that galectin-1 modulates cell adhesions, caveolae, and vascular permeability in kidney endothelial cells through proteomic and phosphoproteomic analyses.

Identification of Ephrin type-B receptor 4 as a critical mediator of tissue fibrosis

This study identifies EphB4 as a critical mediator of pulmonary fibrosis through genetic and pharmacological approaches, showing reduced ECM gene expression and fibrotic pathology.

A cell atlas of human and mouse synovium from early and advanced stages of knee osteoarthritis: BHLHE40 regulates fibroblast activation

This study creates a cellular atlas of synovium in human and mouse knee osteoarthritis, identifying BHLHE40 as a key regulator of fibroblast activation and fibrosis.

Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis

This study uses multi-omic approaches to analyze cellular and transcriptomic diversity in infrapatellar fat pad during knee osteoarthritis, identifying fibroblasts as key contributors to disease-related differences.

Normothermic Ex-vivo Kidney Perfusion in a Porcine Auto-Transplantation Model Preserves the Expression of Key Mitochondrial Proteins: An Unbiased Proteomics Analysis

This study uses proteomics to show that NEVKP preserves mitochondrial proteins and metabolic pathways in porcine kidneys, potentially improving graft function through PPAR-family transcription factors.

Proteomics Reveals Extracellular Matrix Injury in the Glomeruli and Tubulointerstitium of Kidney Allografts with Early Antibody-Mediated Rejection

The paper uses proteomics to identify ECM injury in kidney allografts with early AMR, finding decreased ECM proteins and increased LGALS1 and GSTO1 in affected tissues.

The IMEx Coronavirus interactome: an evolving map of Coronaviridae-Host molecular interactions

The paper curates a dataset of physical molecular interactions between SARS-CoV-2, SARS-CoV-1, and other Coronaviridae proteins, providing a resource for studying virus-host interactions.

Capturing variation impact on molecular interactions: the IMEx Consortium mutations data set

The paper presents a dataset of 28,000 annotations describing how amino acid mutations affect protein interactions, available through the IntAct website.