Author

Iannish D. Sadien

University of CambridgeORCID 0000-0002-3367-1252Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:clustering· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Alan J. SimmonsiD· 1 shared Allan Ramos-EsquiveliD· 1 shared Andrea RolongiD· 1 shared Douglas J. WintoniD· 1 shared George McDonald ChurchiD· 1 shared Hamim ZafariD· 1 shared Ian G. MacaraiD· 1 shared Jeffrey C. RathmelliD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperDevelopmental Biology

Alan J. SimmonsORCID

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2 papers

Recent·Most cited

Prevalence of Colorectal Cancer Molecular Profiles Is Not Captured by a Single Age Threshold

Luis Bermúdez-Guzmán, Iannish D. Sadien, MB BChir, Allan Ramos-Esquivel, Warner Alpízar‐Alpízar

This study shows that age thresholds do not accurately capture molecular profile prevalence in colorectal cancer, finding non-linear and opposing age trajectories for different profiles.

bioRxiv · Aug 27, 2026 · PreprintCancer Biology

Temporal recording of mammalian development and precancer

Mirazul Islam, Yilin Yang, Alan J. Simmons, Vishal M. Shah, Musale Krushna Pavan, Yanwen Xu, Naila Tasneem, Zhengyi Chen, Linh T. Trinh, Paola Molina, Marisol A Ramirez-Solano, Iannish D. Sadien, Jinzhuang Dou, Andrea Rolong, Ken Chen, , Ken S. Lau

The paper introduces NSC-seq, a CRISPR-based molecular clock to track temporal and clonal events in development and precancer, revealing polyancestral initiation in colonic precancers.

Nature · Oct 30, 2024Peer-reviewedDevelopmental Biology