Musale Krushna Pavan

This study maps dynamic changes in murine pancreatic islet cell composition and transcriptional states during hyperglycaemia progression using single-cell multi-omics data.

This study shows that amylin aggregates faster on fibrillar collagen, leading to β-cell death and dysfunction, which accelerates diabetic progression.

multiHIVE integrates CITE-seq data using a hierarchical deep generative model, improving trajectory inference and gene trend identification.

The paper introduces NSC-seq, a CRISPR-based molecular clock to track temporal and clonal events in development and precancer, revealing polyancestral initiation in colonic precancers.

scDREAMER integrates single-cell datasets across batches and species using a deep generative model and adversarial classifier, outperforming existing methods in batch correction and scalability.