Temporal recording of mammalian development and precancer
Mirazul Islam, Yilin Yang, Alan J. Simmons, Vishal M. Shah, Musale Krushna Pavan, Yanwen Xu, Naila Tasneem, Zhengyi Chen, Linh T. Trinh, Paola Molina, Marisol A Ramirez-Solano, Iannish D. Sadien, Jinzhuang Dou, Andrea Rolong, Ken Chen, , Ken S. Lau
The paper introduces NSC-seq, a CRISPR-based molecular clock to track temporal and clonal events in development and precancer, revealing polyancestral initiation in colonic precancers.
Nature · Oct 30, 2024Peer-reviewedDevelopmental Biology