SREBP governs a triglyceride:glycogen metabolic switch in Drosophila
Rupali Ugrankar, Son Tran, Sonakshi Srivastava, Jade Bowerman, Blessy Paul, Lauren G. Zacharias, Thomas P. Mathews, Ralph J. DeBerardinis, W. Mike Henne
This paper shows that blocking lipid synthesis in Drosophila fat body triggers a metabolic switch to glycogen storage, mediated by SREBP and HATs, supporting development but reducing lifespan and fecundity.
bioRxiv · May 13, 2024 · PreprintCell Biology