Occurrence of non-apical mitoses at the primitive streak, induced by relaxation of actomyosin and acceleration of the cell cycle, contributes to cell delamination during mouse gastrulation.
Evangéline Despin‐Guitard, Viviane Souza Rosa, Steffen Plunder, Navrita Mathiah, Kristof Van Schoor, Eliana Nehme, Sara Merino-Aceituno, Joaquim Egea, Marta N. Shahbazi, Eric Théveneau, Isabelle Migeotte
The paper shows that non-apical mitoses in the mouse gastrulation streak, driven by actomyosin relaxation and accelerated cell cycles, contribute to cell delamination, but not mesoderm identity.
Nature Communications · Aug 28, 2024Peer-reviewedDevelopmental Biology